Twitter...do you follow me?
Applications
Being a Mac user I love applications. Here are some of the tools I use religiously - both hosted and local:
Basecamp - Project Collaboration
Kashflow - Online Accounting / Bookkeeping
Coda - Website Development
Tweetdeck - Twitter
Skype - Cheap phone calls
Skitch - Great image screengrabs
JungleDisk - Online data storage
Freshbooks - Billing and Invoicing
1Password - Password / Login Storage
quicksilver - fast hot-key app to everything in the world
Open Source endorsements:
Drupal - CMS
Open Goo - Online Office
VLC Media Player - Entertainment
Other
iStockPhoto - Affordable Stock Images
Macspeech Dictate - Voice recognition/dictation software Mac


Recently read this article on mobile me and gmail. I have to say it is one of the best articles I have read about the negatives of Mobile Me. If you consider them negatives. As a long time gmail user I am reluctant to begin splitting my email experience. gmail offers all the sharing protocols you could possible need - forwarding, imap and Pop.