Office for Mac up the duff...

So after doing something recently I have stuffed my Mac, or something has. It seems to be a prolific problem worldwide this week but still no fix...what to do...

When you click on the icons in the dock or try to open the application from applications folder it just bounces but does not open. This seems to affect Office, Word - Powerpoint - Excel. It also affects my Omnigraffle. Most other things seem OK.

Things I have tried:

Using Fontbook to validate Fonts - all OK there.
Used Yasu to clean and purge all sorts - No difference.
Cleared all Microsoft preferences, basically uninstalled - no difference.
Used Fontfinanlger - no difference
Trying Onyx now....